猪消化道传染病创新团队

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团队成员

郭龙军

1、个人简历

      郭龙军,男,博士,副研究员,猪消化道传染病团队,主要从事猪腹泻病毒等基础免疫学研究。近年来以第一作者发表SCI论文6篇,其中Journal of Virology 论文3篇;主持国家自然科学基金项目及黑龙江省自然科学基金各一项;主持中国农业科学院优秀青年引导项目一项,参与国家自然科学基金项目、黑龙江省自然科学基金等项目多项。

 

2、联系方式

1)研究方向:兽医微生物及其分子生物学

2)电话:0451-51051715

3)邮箱:guolongjun@caas.cn

4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678

 

3、教育经历

2003.09-2007.06  青岛农业大学 动物医学专业 学士

2007.09-2012.06  万博体育max 预防兽医学专业 博士

 

4、工作经历

2012.07-2012.12  中国农科院哈尔滨兽医研究所 研究实习员

2013.01-2016.12  中国农科院哈尔滨兽医研究所 助理研究员

2017.01-至今       中国农科院哈尔滨兽医研究所 副研究员

 

5、承担项目

   1. 国家自然科学基金青年科学基金项目:细胞自噬对猪传染性胃肠炎病毒感染的抑制作用研究(315001282016.01-2018.12),25万元;

   2. 中国农业科学院优秀青年引导项目:猪流行性腹泻病毒(PEDV)抑制Ⅰ型干扰素产生的分子机制研究(Y2017JC052017.01-2019.12),60万元;

   3. 黑龙江省自然科学基金项目:猪源金属蛋白酶ADAM17PEDV感染的抑制作用研究(QC2014C0382016.07-2017.06),5万元。

 

6、代表论文与著作

 1. Longjun Guo, Junwei Niu, Haidong Yu, Weihong Gu, Ren Li, Xiaolei Luo, Mingming Huang, Zhijun Tian, Li Feng, Yue Wang*. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. Journal of Virology. 2014, 88(18): 10448-10458.

2. Longjun Guo, Xiaolei Luo, Ren Li, Yunfei Xu, Jian Zhang, Jinying Ge, Zhigao Bu, Li Feng, Yue Wang*. Porcine epidemic diarrhea virus infection inhibits interferon signaling by targeted degradation of STAT1. Journal of Virology. 2016, 90(18): 8281-8292.

3. Xiaolei Luo#, Longjun Guo#, Jian Zhang, Yunfei Xu, Weihong Gu, Li Feng, Yue Wang*. Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor. Journal of Virology. 2017, 91(10): 00202-00217. (Co-first author)

4. Longjun Guo, Haidong Yu, Weihong Gu, Xiaolei Luo, Ren Li, Jian Zhang, Yunfei Xu, Lijun Yang, Nan Shen, Li Feng, Yue Wang*. Autophagy negatively regulates transmissible gastroenteritis virus replication. Scientific Reports. 2016, 6:23864.

5. Jian Zhang#, Longjun Guo#, Lijun Yang, Jiayu Xu, Lu Zhang, Li Feng, Hongyan Chen, Yue Wang. Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. Virology. 2018,517:24-29. (Co-first author)

6. Weihong Gu#, Longjun Guo#, Ren Li, Junwei Niu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding. Journal of General Virology. 2016, 97(3): 632-638. (Co-first author)

7. Longjun Guo, Yujie Fu, Liping Huang, Yiping Wang, Yanwu Wei, Hongli Wu, Changming Liu*. A commercial PCV2a-based vaccine is effective in protection from experimental challenge of PCV2 mutant with two amino acids elongation in capsid protein. Vaccine. 2015, 33(31): 3752-3757.

8. Weihong Gu, Longjun Guo, Haidong Yu, Junwei Niu, Mingming Huang, Xiaolei Luo, Ren Li, Zhijun Tian, Li Feng, Yue Wang*. Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection. Journal of General Virology. 2015, 96: 1712-1722.

9. Ren Li, Longjun Guo, Weihong Gu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Production of porcine TNFalpha by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Immunologic Research. 2016, 64(3): 711-720.

10. Jian Zhang, Longjun Guo, Yunfei Xu, Lijun Yang, Hongyan Shi, Li Feng*, Yue Wang*. Characterization of porcine epidemic diarrhea virus infectivity in human embryonic kidney cells. Archives of Virology. 2017, 162(8): 2415-2419.

 

 

7、获得奖励

   1. 猪圆环病毒病防控关键技术创新与应用,中国农业科学院科学技术成果一等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军2013年。

   2. 猪圆环病毒2型灭活疫苗产业化开发与推广应用,全国农牧渔业丰收奖二等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军,曲乃昌,刘全胜,成体鸽,陈连和,王云龙,郑新平,闫恒普,耿鸿霜,朱庸康,马平,杨瑞华,顾叶明,李文革,2013年。

   3. 猪圆环病毒疫苗及配套诊断技术的研究与产业化,中华农业科技奖三等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军2013年。

 

(2019年6月更新)

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