猪消化道传染病创新团队

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团队成员

张鑫

 

1、个人简历
张鑫,男,博士学位,副研究员,硕士研究生导师,猪消化道传染病创新团队,研究领域为兽医微生物及其分子生物学,主要从事TGEV、PEDV与PoRV等猪病毒性疫病的诊断和病原学、流行病学、免疫学的研究,以及猪腹泻相关病毒蛋白与宿主蛋白的相互作用研究。承担科研项目4项,发表SCI文章10余篇,获得科研奖励2项,辅助首席培养学生3名。



 
2、联系方式
(1)研究方向:兽医微生物及其分子生物学
(2)电话:15145105603/0451-51051720
(3)邮箱:zhangxin01@caas.cn
(4)通讯地址:哈尔滨市香坊区哈平路678号
 
3、教育经历 
1999.09-2003.06  吉林农业大学大学,动物医学专业,学士
1991.09-1996.06  吉林农业大学大学,预防兽医学专业, 硕士
1991.09-1996.06  浙江大学,预防兽医学专业, 博士
 
4、工作经历
2009.09-2005.12  中国农科院哈尔滨兽医研究所 , 助理研究员
2006.01-至今       中国农科院哈尔滨兽医研究所 , 副研究员
 
5、承担项目
1.“十三五” 国家重点研发计划项目:畜禽重要疫病的微生物组及新发病毒的病原生态学研究(2017YFD0500104,2017.07-2020.12), 50.6万元;
2. 国家自然科学基金:NSP5蛋白与宿主细胞beta tubulin相互作用对PoRV致病性的影响(31502092,2016.01-2018.12),21.6万元(参加);
3. 国家科技支撑(攻关)计划:高致病性蓝耳病等重要家畜疫病新型疫苗研究与开发(2015BAD12B02-6,2015.01-2019.12),100万元(参加);
4. 国家自然科学基金:猪瘟病毒衣壳蛋白核转运机制研究(31101823,2012.01-2015.12),21万元;
 
6、代表论文与著作
1. Zhang Xin, ZhuYunnuan, Zhu Xiangdong, Shi Hongyan, Chen Jianfei, Shi Da, Yuan Jing, Cao Liyan, Liu Jianbo, Dong Hui, Jing Zhaoyang, Zhang Jialin, Wang Xiaobo, Li Feng*. Identification of a Natural Recombinant Transmissible Gastroenteritis Virus between Purdue and Miller Clusters in China. Emerging Microbes and Infectious. 2017. doi:10.1038/emi.2017.62..
2. Zhang Xin, Zhu Yunnuan#, Zhu Xiangdong, Chen Jianfei, Shi Hongyan, Shi Da, Dong Hui, Feng Li*. ORF3a deletion in field strains of porcine transmissible gastroenteritis virus in China: a hint of association with porcine respiratory coronavirus. Transboundary and Emerging Diseases. 2017 Jun; 64(3): 698-702.
3. Zhang Xin, Zhao Xin, Dong Hui, Zhu Yunnuan, Shi Hongyan, Chen Jianfei, Shi Da, Feng Li*. Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein. PLOS One. 2016 Sep 30; 11(9): e0163920.
4. Dong Hui, Zhang Xin#, Shi Hongyan, Chen Jianfei, Shi Da, Zhu Yunnuan, Feng Li*. Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane Protein. Viruses. 2016 Dec 10; 8(12). pii: E327. (#co-first author).
5. Zhang Xin, Shi Hongyan, Chen Jianfei, Shi Da, Dong Hui, Feng Li*. Identification of the interaction between vimentin and nucleocapsidprotein of transmissible gastroenteritis virus. Virus Research. 2015 Mar 16;200:56-63.
6. Zhang Xin, Shi Hongyan, Chen Jianfei,Shi Da, Li Changlong, Feng Li*. EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication. Veterinary Microbiology. 2014 Aug 27; 172(3-4): 443-448.
7. Zhang Xin, Shi Hongyan, Chen Jianfei, Shi Da, Lang Hongwu, Wang Zhongtian, Feng Li*. Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus. Proteome Science. 2013 Jul 16; 11(1): 31.
8. Shi Da,Shi Hongyan,Sun Dongbo,Chen Jianfei,Zhang Xin, Wang Xiaobo,Zhang Jialin,Ji Zhaoyang,Liu Jianbo,Cao Liyan,Zhu Xiangdong,Yuan Jing, Dong Hui,Wang Xin,Chang Tiecheng,Liu Ye,Feng Li*. Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV Growth. Scientific Report. 2017 Jan 3;7:39700.
9. Yuan Jing,Zhang Xin,Shi Hongyan,Chen Jianfei,Han Xiao,Wei Ping ,Feng Li*. The interaction of Rotavirus A pig/China/NMTL/2008/G9P[23] VP6 with cellular beta-actin is required for optimal RV replication and infectivity. Vet Microbiol. 2016 Dec 25; 197: 111-121..
10. Chen Jianfei, Liu Xiaozhen, Shi Da, Shi Hongyan, Zhang Xin, Feng Li*. Complete genome sequence of a porcine epidemic diarrhea virus variant. Journal of Virology. 2012 Mar; 86(6): 3408. doi: 10.1128/JVI.07150-11.
 
7、获得奖励
1. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗 中国农业科学院科学技术成果奖一等奖,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,王洪峰,孙东波,石达,2016年
2. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗的创制与应用 黑龙江省科学技术奖(技术发明类)一等奖,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,王洪峰,孙东波,石达,2017年
 
 
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