猪烈性传染病创新团队

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团队成员

李永锋

1、个人简历

      李永锋:男,汉族,1984110日出生,山东广饶人,博士学位,猪烈性传染病创新团队成员,副研究员,硕士研究生导师。主要从事猪瘟病毒反向遗传学技术的基础和应用研究。主持国家自然科学基金、黑龙江省自然基金等项目4项,累计经费100万元;获得国家发明专利3项;发表第一作者SCI论文13篇,累计影响因子41.5;培养中国农业科学院优秀硕士论文1项。

 

2、联系方式    

1)研究方向:动物疫苗与分子免疫学

2)电话:15204662904, 0451-51051711

3)邮箱:liyongfeng@caas.cn ; 15204662904@126.com

4)所在单位:哈尔滨兽医研究所

5)通讯地址:哈尔滨市香坊区哈平路678

 

3、教育经历

2003.09-2007.06  青岛农业大学   预防兽医学专业   学士

2007.09-2010.06  中国农业科学院研究生院(哈兽研) 预防兽医学专业  硕士

2010.09-2013.06  中国农业科学院研究生院(哈兽研) 预防兽医学专业  博士

 

4、工作经历

2013.07-2016.12  中国农科院哈尔滨兽医研究所  助理研究员

2017.01-至今       中国农科院哈尔滨兽医研究所  副研究员

 

5、承担项目

   1. 国家自然科学基金面上项目:E2蛋白介导的猪瘟兔化弱毒疫苗株适应家兔的分子机制31772774), 62万元, 项目主持人;

   2. 国家自然科学基金青年项目:猪瘟兔化弱毒疫苗株适应家兔的关键基因定位31400146),24万元, 项目主持人;

   3. 黑龙江省自然科学基金青年项目:猪瘟病毒NS5A 蛋白影响病毒复制效率的分子机制(QC2015039),5万元 项目主持人

   4. 哈尔滨市青年后备人才项目:表达非洲猪瘟病毒主要结构蛋白的猪瘟病毒复制子载体疫苗的研究2015RQQYJ056),5万元 项目主持人

 

6、第一作者或并列第一作者代表论文与著作

1. Li Y, Xie L, Zhang L, Wang X, Li C, Han Y, Hu, S, Sun Y, Li S, Luo Y, Liu L, Munir M, Qiu HJ. The E2 glycoprotein is necessary but not sufficient for the adaptation of classical swine fever virus lapinized vaccine C-strain to the rabbit. Virology 2018. Accept, IF=3.353

2. Zhang L, Li Y, Xie L, Wang X, Gao X, Sun Y, Qiu HJ. Secreted expression of the Cap gene of porcine circovirus type 2 in classical swine fever virus C-strain: Potential of C-strain used as a vaccine vector. Viruses. 2017 Oct 16; 9(10). pii: E298. doi: 10.3390/v9100298. PubMed PMID: 29035292. IF=3.4649

3. Li Y, Li LF, Yu S, Wang X, Zhang L, Yu J, Xie L, Li W, Ali R, Qiu HJ. Applications of replicating-competent reporter-expressing viruses in diagnostic and molecular virology. Viruses. 2016 May 6; 8(5). pii: E127. doi:10.3390/v8050127. Review. PubMed PMID: 27164126. IF=3.465

4. Li LF, Yu J, Li Y, Wang J, Li S, Zhang L, Xia SL, Yang Q, Wang X, Yu S, Luo Y, Sun Y, Zhu Y, Munir M, Qiu HJ. Guanylate-binding protein 1, an interferon-induced GTPase, exerts an antiviral activity against classical swine fever virus depending on its GTPase activity. J Virol. 2016 Feb 17. 90, 4412-26. pii: JVI.02718-15. [Epub ahead of print] PubMed PMID: 26889038. IF=4.663

5. Wang X, Li Y, Li LF, Shen L, Zhang L, Yu J, Luo Y, Sun Y, Li S, Qiu HJ. RNA interference screening of interferon-stimulated genes with antiviral activities against classical swine fever virus using a reporter virus. Antiviral Res. 2016 Feb 8; 128:49-56. doi: 10.1016/j.antiviral.2016.02.001. [Epub ahead of print] PubMed PMID: 26868874. IF=4.271

6. Li Y, Wang X, Sun Y, Li LF, Zhang L, Li S, Luo Y, Qiu HJ. Generation and evaluation of a chimeric classical swine fever virus expressing a visible marker gene. Arch Virol. 2016 Mar; 161(3):563-71. doi: 10.1007/s00705-015-2693-7. Epub 2015 Nov 27. PubMed PMID: 26614259. IF=2.058

7. Li Y, Shen L, Sun Y, Wang X, Li C, Huang J, Chen J, Li L, Zhao B, Luo Y, Li S, Qiu HJ. Effects of the nuclear localization of the N(pro) protein of classical swine fever virus on its virulence in pigs. Vet Microbiol. 2014 Dec 5;174(3-4):391-8. doi: 10.1016/j.vetmic.2014.09.027. Epub 2014 Oct 17. PubMed PMID: 25457365. IF=2.511

8. Shen L, Li Y, Chen J, Li C, Huang J, Luo Y, Sun Y, Li S, Qiu HJ. Generation of a recombinant classical swine fever virus stably expressing the firefly luciferase gene for quantitative antiviral assay. Antiviral Res. 2014 Sep;109:15-21. doi: 10.1016/j.antiviral.2014.06.006. Epub 2014 Jun 20. PubMed PMID: 24956495. IF=3.938

9. Li C, Li Y, Shen L, Huang J, Sun Y, Luo Y, Zhao B, Wang C, Yuan J, Qiu HJ. The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit. Virus Res. 2014 Apr;183:117-22. doi: 10.1016/j.virusres.2014.02.003. Epub 2014 Feb 16. PubMed PMID: 24553098. IF=2.324

10. Li Y, Shen L, Li C, Huang J, Zhao B, Sun Y, Li S, Luo Y, Qiu HJ. Visualization of the Npro protein in living cells using biarsenically labeling tetracysteine-tagged classical swine fever virus. Virus Res. 2014 Aug 30;189:67-74. doi: 10.1016/j.virusres.2014.04.018. Epub 2014 May 6. PubMed PMID: 24815879. IF=2.324

11. Li Y, Shen L, Sun Y, Yuan J, Huang J, Li C, Li S, Luo Y, Qiu HJ. Simplified serum neutralization test based on enhanced green fluorescent protein-tagged classical swine fever virus. J Clin Microbiol. 2013 Aug;51(8):2710-2. doi: 10.1128/JCM.00859-13. Epub 2013 May 22. PubMed PMID: 23698523; PubMed Central PMCID: PMC3719638. IF=4.232

12. Li Y, Yin X, Chen X, Li X, Li J, Liu C, Liu M, Zhang Y. Antigenic analysis monoclonal antibodies against different epitopes of sigmaB protein of Muscovy duck reovirus. Virus Res. 2012 Feb; 163(2):546-51. doi: 10.1016/j.virusres.2011.12.006. Epub 2011 Dec 16. PubMed PMID: 22197425. IF=2.745

13. Zhang Y, Li Y, Liu M, Zhang D, Guo D, Liu C, Zhi H, Wang X, Li G, Li N, Liu S, Xiang W, Tong G. Development and evaluation of a VP3-ELISA for the detection of goose and Muscovy duck parvovirus antibodies. J Virol Methods. 2010 Feb; 163(2):405-9. doi: 10.1016/j.jviromet.2009.11.002. Epub 2009 Nov 11. PubMed PMID: 19913055. IF= 2.139

 

7、专利和标准

  1. 仇华吉,申梁, 李永锋,孙元等抗猪瘟病毒感染的siRNA及其应用ZL201410252667.0.

  2. 仇华吉,申梁, 李永锋,孙元等表达萤火虫荧光素酶基因的重组猪瘟病毒及其应用ZL201410252648.8.

  3. 仇华吉,李永锋,孙元等绿色荧光蛋白标记的重组病毒及其拯救方法和应用ZL201310069486.X.

 

(2019年6月更新)

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