马传染病和慢病毒病研究创新团队

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团队成员

张振宇

1、个人简介:
张振宇,男,1987年生,助理研究员,博士后。2005年09月-2009年07月,就读于东北农业大学生物科学专业(本硕博连读),获理学学士学位;2009年09月-2015年07月,就读于东北农业大学生物化学与分子生物学专业,获理学博士学位;2012-2014年获得国家留学基金委公派出国奖学金,在美国国家农业部(USDA)学习交流。2015年07月至今,万博体育max,助理研究员,研究方向为流感病毒与宿主天然免疫。
主要从事流感病毒与宿主天然免疫的研究,通过筛选与流感病毒蛋白互作的宿主蛋白,探索宿主天然免疫与病毒复制之间的关系。可为抗流感病毒药物的研发提供新思路。
先后主持和参加国家自然基金青年项目、面上项目4项,发表SCI论文10篇,参编专著2部。 
2、联系方式
(1)研究方向:流感病毒与宿主天然免疫
(2)电话:0451-51051751
(3)邮箱:zhangzhenyu@caas.cn
(4)通讯地址:黑龙江哈尔滨香坊区哈平路678号
 
3、教育经历 
2015--至今  哈尔滨兽医研究所 马病与慢病毒研究团队 博士后
2014--2015 东北农业大学 生物化学与分子生物学 博士(本硕博连读)
2012--2014 USDA-ARS, Southeast Poultry Research Laboratory, U.S.A.; Ph.D.
2011--2012 东北农业大学 生物化学与分子生物学 博士(本硕博连读)
2009--2011 东北农业大学 生物化学与分子生物学 硕士(本硕博连读)
2005--2009 东北农业大学 生物科学 学士(本硕博连读)
 
4、工作经历
      2015.07-至今 中国农科院哈尔滨兽医研究所 助理研究员
 
5、承担项目
(1)国家自然科学基金青年科学基金项目,31702269,A型流感病毒NS1蛋白通过结合宿主LRPPRC蛋白影响病毒复制机制的研究,2018.01-2020.12,25万元,在研,主持;
(2)国家自然科学基金创新研究群体科学基金,31521005,动物传染病,2016.01-2021.12,1200万元,在研,参与;
(3)国家自然科学基金面上项目,31772720,microRNA-27a和microRNA-92a在EIAV强弱毒诱导宿主差异炎症反应中的作用机制研究, 2018.01-2021.12,57万元,在研,参与;
(4)国家自然科学基金青年科学基金项目,31602034,马TRIM5α参与抗病毒天然免疫应答的分子机制研究,2017.01-2019.12,21万元,在研,参与;
6、代表性研究论文:
(1) Zhenyu Zhang; Wei Zhao; Deshan Li; Yu, Q. Development of a Newcastle disease virus vector expressing a foreign gene through an internal ribosomal entry site provides direct proof for a sequential transcription mechanism. Journal of General Virology. Published April 13, 2015 as doi:10.1099/vir.0.000142
(2) Zhenyu, Zhang, Deshan, Li., Zsak, L Qingzhong, Yu. A Novel Approach for Expression of a Foreign Gene by Newcastle Disease Virus. In: Proceedings of 2014 annual meeting of American Association of Avian Pathologists, Denver, CO, U.S.A. CD-ROM, p.97-98. July 27, 2014.
(3) Yunzhou Wu; Jinjiao He; Ying An; Xianlong Ye; Qingzhong Yu; Jiechao Yin; Zhenyu Zhang*; Deshan Li*. Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy. Eur J Pharmacol. 2017 May 5;802:85-92. doi: 10.1016/j.ejphar.2017.02.042.
(4) Wen, G., Hu, X., Zhao, K., Wang, H., Zhang, Z., Zhang, T., Yang, J., Luo, Q., Zhang, R., Pan, Z., Shao, H., and Yu, Q. Molecular basis for the thermostability of Newcastle disease virus. Sci. Rep. 6, 22492; doi: 10.1038/srep22492. 2016 
(5) Guoyuan Wen, Zhenyu Zhang(Co-first author), Chen Chen, Jing Guo, Yu Shang, Huabin Shao, Qingping Luo, Jun Yang, Hongling Wang, Hongcai Wang, Tengfei Zhang, Rongrong Zhang, Guofu Cheng, Qingzhong Yu. Development of a Novel Thermostable Newcastle Disease Virus Vaccine Vector for Expression of a Heterologous Gene. Journal of General Virology. J Gen Virol. 2015 Jan 27. pii: vir.0.000067. doi: 10.1099/vir.0.000067.
(6) Wei, Zhao, Zhenyu, Zhang (Co-first author), Zsak, L., and Qingzhong, Yu. P and M gene junction is the optimal insertion site in Newcastle disease virus vaccine vector for foreign gene expression. Journal of General Virology. J Gen Virol. 2015 Jan;96(Pt 1):40-5. doi: 10.1099/vir.0.068437-0. Epub 2014 Oct 1. 
(7) Jingzhuang Zhao; Liming Xu; Miao Liu; Zhenyu Zhang; Jiasheng Yin; Hongbai Liu; Tongyan Lu. Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line. Dev Comp Immunol. 2017 Jul 29;77:88-94. doi: 10.1016/j.dci.2017.07.025.
(8) Wei Zhao, Stephen Spatz, Zhenyu Zhang, Guoyuan Wen, Maricarmen Garcia, Laszlo Zsak, and Qingzhong Yu. Newcastle disease virus (NDV) recombinants expressing infectious laryngotracheitis virus (ILTV) gB and gD glycoproteins protect chickens against ILTV and NDV challenge. Journal of Virology, 2014. 88(15) 8397-8406. 2014.
(9) Zhao, W., Zhang, Z., Zsak, L., and Yu, Q. Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence. Virus Genes, 47(3):498-504. 2013.
(10) Toro, H., Zhao, W., Breedlove, C., Zhang, Z., van Santen, V. L. and Yu, Q. Infectious bronchitis virus S2 expressed from recombinant virus confers broad protection against challenge. Avian Diseases, 58(1):83-9. 2014.
(11) Zhu, S; Zhang, Z; Ren, G; Ye, X; Ma, L; Yu, D; Li, D. Therapeutic effect of fibroblast growth factor 21 on NAFLD in MSG-IR mice and its mechanism. 48 (12): 1778-1784.2013.
(12) Zhu, S; Ren, G; Zhang, Z; Wang, W; Ye, X; Li, D. Therapeutic effect of fibroblast growth factor 21 on hypertension induced by insulin resistance. Acta Pharmaceutica Sinica. 48(9):1409?1414.2013.
(13) LI, J; Zhang, Z; Wang, W; Chen, R; LI, D; Dynamic FGF21 Expression under Exercise,Fasting and Food Components, ,Chinese Journal of Biochemistry and Molecular Biology. 28(9): 843-849.2012.
(14) Sun, G; Ren, G; Ye, X; Zhang, Z; LI, D. The Establishment of the slow onset rat model reflecting pathogenesis of type 1 diabetes mellitus. Chinese Journal of Biochemistry and Molecular Biology. 26(4):560-560.2010.
(15) Li, J; Zhang, Z; Li, D. Human Fibroblast Growth Factor-21 Regulates Glucose Uptake in 3T3-L1 Adipocytes. Chinese Journal of Biochemistry and Molecular Biology, 25(6):556-562. 2009
 
7、获得奖励
   国家留学基金委公派出国奖学金,国家留学基金委,张振宇,2012年
 
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