动物细菌病研究创新团队

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团队成员

张跃灵

 


1、个人简历
张跃灵,女,博士,副研究员,硕士生导师,万博体育max动物细菌病创新团队骨干一级成员。主持国家自然科学基金等项目4项,发表SCI文章10篇(其中以第1或通讯作者发表SCI文章7篇,累计影响因子23),培养研究生4名。

 

2、联系方式
(1)研究领域:动物细菌病
(2)研究方向:链球菌致病机理与防控技术研究
(3)电话:0451-51051731
(4)邮箱:zhangyueling@caas.cn; zhang.yl@foxmail.com
(5)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号哈尔滨兽医研究所综合楼5008,150069
 
3、教育经历 
1996.09-2000.07    河南农业大学             农产品贮运与加工  学士 
2000.09-2003.07    河南农业大学             微生物学          硕士 
2003.09-2009.04    中国科学院微生物研究所   微生物学          博士 
 
4、工作经历
2008.10-2010.01    中国科学院天津工业生物技术研究所        助理研究员
2010.01-2013.02    美国圣母大学W. M. Keck转基因研究中心    博士后
2013.07-2014.10    黑龙江省农业科学院畜牧研究所            副研究员
2014.10至今        万博体育max          副研究员
 
5、承担项目
1)国家自然科学基金面上项目:猪链球菌的eSTK/eSTP系统对反应调节因子CovR的调控及其机制研究(31772757,2018.01 -2021.12),62万,在研。
2)“十三五”国家重点研发计划:“畜禽重要病原菌的病原组学与网络调控研究”项目(2017YFD0500200)子课题“病原菌毒力调控机制研究”(2017YFD0500203,2017.07-2021.12),105万,在研。
3)国家自然科学基金青年项目:SK2b型A族链球菌激活纤溶酶原的分子机制的研究(31500112,2016.01-2018.12),19万,在研。
4)黑龙江省科学基金面上项目:2型猪链球菌SSU05_0196蛋白结合纤溶酶原及介导血行播散的分子机制(C2017075,2017.10-2020.10),6万,在研。
 
6、代表论文与著作
1)Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu*, and Yueling Zhang*, Activity of sortase A from Streptococcus suis is Ca2+-independent and strongly inhibited by aceteoside, isoquercitrin and baicalin, PLoS ONE, 2017; 12(3): e0173767.
2)Yueling Zhang, Jeffrey Mayfield, Victoria A. Ploplis, and Francis J. Castellino. The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. Biochemical and Biophysical Research Communications, 2014; 444(4):595-8.
3)Yueling Zhang, Zhong Liang, Kristofor Glinton, Victoria A. Ploplis, Francis J. Castellino. Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. FEBS Letters, 2013; 587(9):1304-9.
4)Zhong Liang#, Yueling Zhang#, Garima Agrahari, Vishwanatha Chandrahas, Kristofor Glinton, Deborah L. Donahue, Rashna D. Balsara, Victoria A. Ploplis, and Francis J. Castellino. A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. The Journal of Biological Chemistry, 2013; 288(9):6561-73. 
5)Yueling Zhang, Zhong Liang, Hsing-Tse Hsueh, Victoria A. Ploplis, and Francis J. Castellino. Characterization of streptokinases from group A streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M-protein and cluster 2B streptokinase. The Journal of Biological Chemistry, 2012; 287(50): 42093-103. 
6)Yueling Zhang, Jiansong Ju, Hao Peng, Feng Gao, Cheng Zhou, Yan Zeng, Yanfen Xue, Yin Li, Bernard Henrissat, George F. Gao, Yanhe Ma. Biochemical and structural characterization of the intracellular mannanase AaManA reveals a novel glycoside hydrolase family belonging to GH-A superfamily. The Journal of Biological Chemistry, 2008; 283(46): 31551-58. 
7)Yueling Zhang, Feng Gao, Yanfen Xue, Yan Zeng, Hao Peng, Jianxun Qi and Yanhe Ma. Crystallization and preliminary X-ray study of a mannanase from Alicyclobacillus acidocaldarius Tc-12-31. Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 2008; 64(3): 209-12.
8)Martina L Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Victoria Ploplis, Mark Walker, Francis Castellino. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLOS Pathogen, 2013; 9(7): e1003469.
9)Yingying Zheng, Yanfen Xue, Yueling Zhang, Cheng Zhou, Ulrich Schwaneberg, Yanhe Ma. Cloning, expression, and characterization of a thermostable glucoamylase from Thermoanaerobacter tengcongensis MB4. Applied Microbiology and Biotechnology, 2010; 87(1): 225-33.
10)Cheng Zhou, Yanfen Xue, Yueling Zhang, Yan Zeng, and Yanhe Ma. Recombinant expression and characterization of Thermoanaerobacter tengcongensis thermostable α-glucosidase with regioselectivity for high-yield isomaltooligosaccharides synthesis. Journal of Microbiology and Biotechnology, 2009; 19(12): 1547-56.
 
7、获得奖励
1)酶-寡糖-益生菌三效复合饲用抗生素替代技术,湖北省科技进步二等奖,马延和,张桂敏,詹志春,宋诙,周樱,薛燕芬,张跃灵,方程,望潇文,顾爱玲,2016年。
 
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