动物细菌病研究创新团队

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团队成员

谢 芳

1、个人简历

谢芳,女,博士,副研究员,硕士生导师,动物细菌病研究创新团队科研骨干。研究领域为猪源细菌病的感染与免疫机制及防控技术研究,主持国家自然科学基金和黑龙江省科学基金等课题3项,发表文章20余篇,其中以第1作者发表SCI文章10篇。获得国家发明专利9项,获得省市级奖励3项。

 

2、联系方式    

1)研究方向:兽医微生物及其分子生物学

2)电话:0451-51051731

3)邮箱:xiefang@caas.cn

4)所在单位:万博体育max

5)通讯地址:哈尔滨市香坊区哈平路678号哈尔滨兽医研究所综合楼,150069

 

3、教育经历

2001.09-2005.06  河北科技师范学院  动物医学专业 学士

2005.09-2007.06  吉林大学 预防兽医学专业 硕士

2007.09-2010.06  吉林大学 预防兽医学专业 博士

 

4、工作经历

2010.07-2017.12  中国农科院哈尔滨兽医研究所 助理研究员

2018.01-至今       中国农科院哈尔滨兽医研究所  副研究员

 

5、承担项目

   1. 国家自然科学基金面上项目:猪链球菌2型半胱氨酸蛋白酶ApdS切割宿主防御肽cathelicidin LL-37介导其免疫逃逸的分子机制(318730162019.01-2022.12, 67万元;

   2. 国家自然科学基金青年科学基金项目:猪胸膜肺炎放线杆菌ClpP蛋白酶的致病机理研究(311001032012.01-2014.12),24万元;

  3. 黑龙江省科学基金青年项目:猪链球菌2SSU05_1311蛋白与纤连蛋白互作介导其黏附和侵入宿主细胞的分子机制(QC20160442016.07-2019.07),5万元;

 

6、代表论文与著作

     1. Fang Xie, Yalei Wang, Gang Li, Shuanghong Liu, Ning Cui, Siguo Liu, Paul R. Langford and Chunlai Wang. The SapA protein is involved in resistance to antimicrobial peptide PR-39 and virulence of Actinobacillus pleuropneumoniae. Frontiers in Microbiology. 2017, 8: 811.

     2. Fang Xie, Gang Li, Yalei Wang, Yanhe Zhang, Long Zhou, Chengcheng Wang, Shuanghong Liu, Siguo Liu, Chunlai Wang. Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence. PLoS One. 2017, 12(4): e0176374.

     3. Fang Xie, Gang Li, Long Zhou, Yanhe Zhang, Ning Cui, Siguo Liu, Chunlai Wang. Attenuated Actinobacillus pleuropneumoniae double-deletion mutant S-8∆clpP/apxIIC confers protection against homologous or heterologous strain challenge. BMC Veterinary Research. 2017, 13(1): 14.

     4. Gang Li#Fang Xie#, Jianjun Li, Jiao Liu, Dapeng Li, Yanhe Zhang, Paul R. Langfordb, Yanwen Li, Siguo Liu, Chunlai Wang. Identification of novel Haemophilus parasuis serovar 5 vaccine candidates using an immunoproteomic approach. Journal of Proteomics.2017, 163: 111-117.

     5. Fang Xie, Gang Li, Wanjiang Zhang, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang. Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of Actinobacillus pleuropneumoniae. Veterinary Microbiology. 2016, 183: 1-8,

     6. Fang Xie, Gang Li, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang. The Lon protease homologue LonA, not LonC, contributes to the stress tolerance and biofilm formation of Actinobacillus pleuropneumoniae. Microbial Pathogenesis. 2016, 93: 38-43.

     7. Fang Xie, Yanhe Zhang, Gang Li, Siguo Liu, Chunlai Wang. The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. PLoS One. 2013, 8(1): e53600.

     8. FengYang#Fang Xie#, Yuwen Jiang, Suqing Li, Yanping Xing, Yu Wang, Xin Feng, Wenyu Han, Liancheng Lei. Genomic Differences Between Actinobacillus pleuropneumoniae Serotypes 5b and 3 and their Distribution and Transcription Among 15 Serotypes. Current Microbiology. 2011, 63(4): 327-331.

     9. Fang Xie, Liancheng Lei, Chongtao Du, Shuqing Li, Wenyu Han, Zhiyan Ren. Genomic differences between Actinobacillus pleuropneumoniae serotypes 1 and 3 and the diversity distribution among 15 serotypes. FEMS Microbiology Letters. 2010, 303(2): 147-155.

10. Fang Xie, Mingjun Zhang, Shuqing Li, Chongtao Du, Changjiang Sun, Wenyu Han, Liang Zhou, Liancheng Lei. Differentially expressed genes in the pathogenic strains of Actinobacillus pleuropneumoniae serotypes 1 and 3. Journal of Microbiology and Biotechnology. 2010, 20(4): 789-797.

11. Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu, Yueling Zhang. Streptococcus suis sortase A is Ca2+ independent and is inhibited by acteoside, isoquercitrin and baicalin. PLoS One. 2017, 12(3): e0173767.

12. Gang Li, Fang Xie, Yanhe Zhang, Janine T. Bossé, Paul R. Langford, and Chunlai Wang. Role of (p)ppGpp in viability and biofilm formation of Actinobacillus pleuropneumoniae S8. PLoS One.  2015, 10(10): e0141501.

13. Gang Li, Fang Xie, Yanhe Zhang, Chunlai Wang, Draft genome sequence of Actinobacillus pleuropneumoniae serotype 7 strain S-8. Journal of Bacteriology. 2012, 194(23): 6606-6607.

14. Yanhe Zhang, Gang Li, Fang Xie, Siguo Liu and Chunlai Wang. Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model. Journal of veterinary medical science. 2017, 79(1):184-187.

15. Mingming Hu, Yanhe Zhang, Fang Xie, Gang Li, Jianjun Li, Wei Si, Siguo Liu, Shouping Hu, Zhuo Zhang, Nan Shen, Chunlai Wang. Protection of piglets by a Haemophilus parasuis ghost vaccine against homologous challenge. Clinical and Vaccine Immunology. 2013, 20(6):795-802.

 

7、专利和标准

     1. 谢芳,王春来,张艳禾,李建军,朱晓凯,李艳玲, 一种不含抗性标记的猪胸膜肺炎放线杆菌ClpP蛋白酶基因缺失株、其构建方法及应用,ZL 201110336861.3

2. 王春来,谢芳,李刚,张艳禾,一种不含抗性标记的猪传染性胸膜肺炎弱毒活疫苗及其用途,ZL 201310469680.7

3. 王春来,谢芳,张艳禾,李刚,一种不含抗性标记的猪胸膜肺炎放线杆菌双基因缺失株、其构建方法及应用,ZL 201110420236.7

4. 王春来,李刚,张艳禾,谢芳,一种副猪嗜血杆菌病亚单位疫苗组合物及应用,ZL 201310406551.3

5. 王春来,李刚,张艳禾,谢芳,一种制备副猪嗜血杆菌病菌影疫苗的方法及其产品和应用,ZL 201310409237.0

6. 王春来,李刚,张艳禾,谢芳, 一种副猪嗜血杆菌免疫保护性抗原AfuAZL 20131 0268347.X

7. 李刚,王春来,张艳禾,谢芳,一种副猪嗜血杆菌免疫保护性抗原HbpAZL 20131 0268864.7

8. 王春来,李刚,张艳禾,谢芳,一种副猪嗜血杆菌免疫保护性抗原OppAZL 20131 0268863.2

9. 王春来,李刚,张艳禾,谢芳, 一种副猪嗜血杆菌免疫保护性抗原OppA2ZL 2013 10268810.0

 

8、获得奖励

    1. 猪传染性胸膜肺炎菌影疫苗的研制及其应用,黑龙江省科技进步三等奖,王春来,李刚,谢芳,张艳禾,李艳玲,周泷,2017

    2. 猪传染性胸膜肺炎菌影疫苗的研制及其应用,哈尔滨市科技进步二等奖,王春来,李刚,谢芳,张艳禾,李艳玲,周泷,2016

    3. 基于比较基因组学的胸膜肺炎放线杆菌黏附致病机制及异源免疫研究,吉林省自然科学学术成果奖二等奖,雷连成,冯新,杨舒心,谢芳,王瑜,杜崇涛,孙长江,翟瑞东,李林溪,王磊,杨鹏,周靓,韩文瑜,2014

 

(2019年6月更新)

 
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