动物流感基础与防控研究创新团队

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团队成员

曾显营

 
1、个人简历
曾显营,男,博士,副研究员,硕士生导师,动物流感基础与防控研究团队研究骨干,2006年以来,一直致力于事禽流感病毒变异和防控疫苗的研究工作;主持和参加国家自然基金、黑龙江省自然基金、十三五国家重点研发计划、国家现代农业产业技术体系等多项禽流感研究项目;近年来,在Science, JVI, Vaccine等国际专业杂志上发表SCI论文19篇,为PLOS one杂志审稿专家;研制禽流感系列疫苗和诊断试剂10余种,获新兽药证书4项,居国际或国内领先水平,其中H5亚型禽流感系列疫苗已在我国和东南亚、埃及等国家广泛应用,生了巨大的经济和社会效益;获得黑龙江省科技进步一等奖(2010年)和三等奖(2015)各1项,获中国农业科学院杰出科技创新奖1项(2015年)。
 

2、联系方式
(1)研究方向:动物疫苗与分子免疫学
(2)电话:0451-51991678
(3)邮箱:zengxianying@caas.cn
(4)通讯地址:哈尔滨市香坊区哈平路678号,150069
 
3、教育经历
1999.09~2003.07 河南农业大学牧医工程学院 动物医学 学士学位
2003.09~2006.07 扬州大学兽医学院 预防兽医学获 硕士学位
2010.09~2013.12 中国农业科学院研究生院 预防兽医学 博士学位
 
4、工作经历
2006.07~2009.12 万博体育max 研究实习员
2009.12~2015.12 万博体育max 助理研究员
2016.01 ~今         万博体育max 副研究员
 
5、承担项目
(1) 国家自然科学基金面上项目,31672593,H5亚型禽流感病毒同义HA的设计及其免疫特性研究,2017/1 -2020/12,62万元,项目负责人
(2) 国家重点研发计划项目,2017YFD0500700,鸡重要疫病免疫防控新技术研究,2017/7-2020/12,2073万元,课题骨干
(3) 现代农业产业技术体系,CARS-41-G12,肉鸡体系禽流感防控, 2016/1-2020/12,350万元,项目骨干
 
6、代表性文章
(1) Shi J?, Deng G?, Kong H?, Gu C?, Ma S?, Yin X?, Zeng X, Cui P, Chen Y, Yang H, Wan X, Wang X, Liu L, Chen P, Jiang Y, Liu J, Guan Y, Suzuki Y, Li M, Qu Z, Guan L, Zang J, Gu W, Han S, Song Y, Hu Y, Wang Z, Gu L, Yang W, Liang L, Bao H, Tian G, Li Y, Qiao C, Jiang L, Li C, Bu Z, Chen H. 2017. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research doi:10.1038/cr.2017.129.
(2) Zeng X, Deng G, Liu L, Li Y, Shi J, Chen P, Feng H, Liu J, Guo X, Mao S, Yang F, Chen Z, Tian G, Chen H*. 2016. Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 Against Different Clades of H5N1 Viruses Isolated in China and the Democratic People's Republic of Korea. Avian Diseases 60:238-240.
(3) Zeng X, Chen P, Liu L, Deng G, Li Y, Shi J, Kong H, Feng H, Bai J, Li X, Shi W, Tian G, Chen H*. 2016. Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens. Avian Diseases 60:253-255.
(4) Liu L?, Zeng X?, Chen P, Deng G, Li Y, Shi J, Gu C, Kong H, Suzuki Y, Jiang Y, Tian G, Chen H*. 2016. Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue to Circulate in Chickens in China. Journal of Virology doi:10.1128/JVI.00855-16.
(5) Zhao Y, Wang X, Chen P, Zeng X, Bao H, Wang Y, Xu X, Jiang Y, Chen H*, Li G. 2015. Detection of antibodies against avian influenza virus by protein microarray using nucleoprotein expressed in insect cells. The Journal of veterinary medical science / the Japanese Society of Veterinary Science 77:413-419.
(6) Xu X, Bao H, Ma Y, Sun J, Zhao Y, Wang Y, Shi J, Zeng X, Li Y, Wang X, Chen H*. 2015. Simultaneous detection of novel H7N9 and other influenza A viruses in poultry by multiplex real-time RT-PCR. Virology journal 12:69.
(7) Wen Z, Wu C, Chen W, Zeng X, Shi J, Ge J, Chen H, Bu Z*. 2015. Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin. Biotechnology research international 2015:402628.
(8) Wen X, Sun J, Wang X, Bao H, Zhao Y, Zeng X, Xu X, Ma Y, Gu L, Chen H*. 2015. Identification of a novel linear epitope on the NS1 protein of avian influenza virus. BMC microbiology 15:168.
(9) Bao H, Ma Y, Shi J, Zeng X, Zhao Y, Wang X, Chen H*. 2015. Evaluation and application of a one-step duplex real-time reverse transcription polymerase chain reaction assay for the rapid detection of influenza A (H7N9) virus from poultry samples. Archives of virology 160:2471-2477.
(10) Shi J, Deng G, Zeng X, Kong H, Wang X, Lu K, Wang X, Mu G, Xu X, Cui P, Bao H, Tian G, Chen H*. 2014. Novel influenza A(H7N2) virus in chickens, Jilin province, China, 2014. Emerging infectious diseases 20:1719-1722.
(11). Bao H, Zhao Y, Wang Y, Xu X, Shi J, Zeng X, Wang X, Chen H*. 2014. Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of subtype H7N9 avian influenza virus. BioMed research international 2014:525064.
(12) Zhang Q?, Shi J?, Deng G?, Guo J?, Zeng X?, He X, Kong H, Gu C, Li X, Liu J, Wang G, Chen Y, Liu L, Liang L, Li Y, Fan J, Wang J, Li W, Guan L, Li Q, Yang H, Chen P, Jiang L, Guan Y, Xin X, Jiang Y, Tian G, Wang X, Qiao C, Li C, Bu Z, Chen H*. 2013. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science 341:410-414.
(13) Shan S, Jiang Y, Bu Z, Ellis T, Zeng X, Edwards J, Tian G, Li Y, Ge J, Chen H*, Fenwick S. 2011. Strategies for improving the efficacy of a H6 subtype avian influenza DNA vaccine in chickens. Journal of virological methods 173:220-226.
(14) Liu J?, Chen P?, Jiang Y, Wu L, Zeng X, Tian G, Ge J, Kawaoka Y, Bu Z, Chen H*. 2011. A duck enteritis virus-vectored bivalent live vaccine provides fast and complete protection against H5N1 avian influenza virus infection in ducks. Journal of virology 85:10989-10998.
(15) Li Y, Liu L, Zhang Y, Duan Z, Tian G, Zeng X, Shi J, Zhang L, Chen H*. 2011. New avian influenza virus (H5N1) in wild birds, Qinghai, China. Emerging infectious diseases 17:265-267.
 
7、获得奖励
(1)禽流感(H5+H9)二价灭活疫苗(H5N1 Re-1+H9N2 Re-2株),黑龙江省科学技术进步一等奖,陈化兰、田国彬、李雁冰、施建忠、曾显营、冯菊艳、姜永萍、邓国华、王秀荣、乔传玲,2010年。
(2)我国H5N1亚型高致病性禽流感病毒抗原变异株的鉴定及防控研究,黑龙江省科学技术进步二等奖,陈化兰、李雁冰、田国彬、施建忠、曾显营、姜永萍、刘丽玲,2011年。
(3)动物流感病毒引起人流感大流行的潜力及其遗传机制,中国农业科学院杰出科技创新奖,陈化兰、施建忠、邓国华、李雁冰、李呈军、曾显营、刘丽玲、姜永萍、何希君、田国彬、关云涛、柳金雄、陈普成、陈艳、杨焕良,2015年
 
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