动物病原监测与流行病学研究团队

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团队成员

王 刚

1、个人简历

    王刚,男,博士,副研究员,硕士生导师,动物病原监测与流行病学团队。长期从事猪繁殖与呼吸综合征病毒、猪圆环病毒等致病与免疫机制的研究。近年来,先后主持国家自然科学基金项目、黑龙江省自然科学基金等项目。在J Gen VirolTransbound Emerg DisDev Comp ImmunolMicrobiol ResVet Microbiol等专业杂志发表科技论文20多篇,被国际同行引用100多次。

 

2、联系方式

1)研究方向:动物传染病及其病原分子流行病学

2)电话:0451-51051768

3)邮箱:wanggang@caas.cn

4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678

 

3、教育经历 

2002.09–2006.06,山东农业大学,动物医学,本科。

2006.09–2011.06,山东农业大学,预防兽医学,博士。

 

4、工作经历

2011.07-2016.12,万博体育max,助理研究员;

2017.01-至今,万博体育max,副研究员;

2018/03-2018/03,美国Iowa State University,访问学者。

 

5、承担项目

 1)国家自然科学基金青年基金项目、31201885、高致病性PRRSVHuN4 株)对仔猪中枢免疫器官的感染及损伤机制的研究、2013/01-2015/1223万元、主持;

 2)高致病性PRRSV驱动胸腺细胞程序性死亡的分子机制、黑龙江省自然科学基金(面上)项目、C20160682016/ 07-2019/07 6万元、主持;

 3)国家科技支撑计划,2015BAD11B00,新型动物专用生物药物的创制及产业化关键技术研究,2015/ 04-2019/12635万元,项目骨干。

 

6、代表论文与著作

 1)      Wang G*, Yu Y, He X, Wang M, Cai X, Zimmerman JJ*, Porcine reproductive and respiratory syndrome virus infection of bone marrow: Lesions and pathogenesis. Virus Research. 2019, 265: 20-29

 2)      Wang HM#, Liu YG#, Tang YD, Liu TX, Zheng LL, Wang TY, Liu SG, Wang G*, Cai XH*. A natural recombinant PRRSV between HP-PRRSV JXA1-like and NADC30. Transbound Emerg Dis. 2018, doi: 10.1111/tbed.12852. (*:共同通讯作者)

 3)      Tong J#, Yu Y#, Zheng LL#, Zhang C, Tu YB, Liu YG, Wu JN, Li H, Wang SJ, Jiang CG, Zhou E-M, Wang G*, Cai XH*. Hypothalamus-pituitary-adrenal axis involves in anti-viral ability through regulation of immune response in piglets infected by highly pathogenic porcine reproductive and respiratory syndrome virus. BMC Vet Res. 2018, 14:92. (*:共同通讯作者)

 4)      Tu YB#*, Wang G#, Wang YQ, Chen WY, Zhang L, Liu YG, Jiang CG, Wang SJ, Bu ZG, Cai XH*. Extracellular expression and antiviral activity of a bovine interferon-alpha through codon optimization in Pichia pastoris. Microbiol Res. 2016, 191: 12-18. (#:共同第一作者)

 5)      Wang G, Yu Y, Zhang C, Tu YB, Tong J, Liu YG, Chang YF, Jiang CG, Wang SJ, Zhou E-M*, Cai XH*. Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain. Dev Comp Immunol. 2016, 62: 1-7. doi: 10.1016/j.dci.2016.04.019.

 6)      Dong JG#, Wang G#, Liu YG, Shi WD, Wu JN, Wen HQ, Wang SJ, Tian ZJ, Cai XH*. Quantitative estimation of the replication kinetics of genotype 2 PRRSV strains with different levels of virulence in vitro. J Virol Methods. 2016, 234: 87-9. (#:共同第一作者)

 7)      Wang G, Li L, Yu Y, Tu YB, Tong J, Zhang C, Liu YG, Li YM , Han ZF, Jiang CG, Wang SJ, Zhou E-M, He XJ*, Cai XH*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection and induction of apoptosis in bone marrow cells of infected piglets. J Gen Virol. 2016, 97: 1356-1361.

 8)      Wang G, Yu Y, Tu YB, Li YM, Tong J, Zhang C, Liu YG, Li AD, Jiang CG, Wang SJ, Tao Y, Cai XH*.Characterizing the thymic lesions in piglets infected with attenuated strains of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol.2015, 15(3-4): 258-61.

 9)      Wang G, Yu Y, Tu Y, Tong J, Liu Y, Zhang C, Chang Y, Wang S, Jiang C, Zhou EM*, Cai X*. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets. PLoS One. 2015, 10, e0128292.

 10)   Li Y#, Wang G#, Liu Y, Tu Y, He Y, Wang Z, Han Z, Li L, Li A, Tao Y, Cai X*. Identification of apoptotic cells in the thymus of piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Virus Res. 2014, 189:29-33. (#:共同第一作者)

 11)   Wang G, He YL, Tu YB, Liu YG, Zhou EM, Han ZF, Jiang CG, Wang SJ, Shi WD, Cai XH*. Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus. Virol J. 2014, 11:2.

 12)  Wang G, Song TF, Yu Y, Liu YG, Shi WD, Wang SJ, Rong FL, Dong JG, Cai XH*, Zhou EM*. Immune Responses in Piglets Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome. Vet Immunol Immunopathol. 2011, 142(3-4):170-8.

 13)   Li Z, Wang G, Wang Y, Zhang C, Huang B, Li Q, Li L, Xue B, Ding P, Cai X, Wang C, Zhou EM. Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol. 2015, 168(1-2): 40-8.

 14)  Yu Y, Wang G, Li Q, Du Y, Du T, Mu Y, Xiao S, Zhao Q, Wang C, Sun Yi, Xu X, Zhang G, Hsu WH, Cai X, Zhou E-M. Single-chain antiidiotypic antibody retains it specificity to porcine reproductive and respiratory syndrome virus GP5. Immunol Lett. 2015, 163(4): 8-13.

 15)  Li Z, Wang G, Wang Y, Zhang C, Wang X, Huang B, Li Q, Li L, Xue B, Ding, P, Syed SF, Wang C*, Cai X*, Zhou EM*. (2015b). Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin-4. Virol J 12, 185.

 

(2019年6月更新)

 

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